The NFL appears to be loading up its schedule with division games once again, as for the second week in a row there are only two division matchups you can target for your NFL betting and NFL predictions for Week 6. Steelers vs. Browns (+6) is the only one on Sunday. Other Week 6 NFL spreads of at least 5 points include Rams vs. Ravens (+7), Lamar Jackson ruled out, Colts vs. Cardinals (+9.5) with Kyler Murray (leg) listed as questionable, and Packers vs. Bengals (+14.5), with Joe Flacco making his starting debut “Cinxi” in the center.
The latest of these matchups is the seventh game this year with an NFL line over 9 points, and the favorites in these matchups are 3-3 ATS. So, this NFL betting trend won't help your Week 6 NFL predictions much, but there are others that can certainly help with football betting. All of the updated Week 6 NFL lines are listed below, and SportsLine's advanced computer model has all the betting tips and NFL predictions you need. make your best NFL Week 6 picks now.
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The model, which simulates every NFL game 10,000 times, costs more than $7,000 for players with $100 in top games. NFL Pick since its creation. The model has a stunning 41-21 record in top-ranked picks since 2024. Anyone who follows her NFL Betting poking around in bookmakers and further betting sites could see strong profits.
Now he turned his attention to the latest NFL Week 6 Odds and NFL betting lines, as well as fixed betting options for every NFL matchup. Head here to see each selection..
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The best NFL predictions for Week 6
We can tell you that one of the model's strongest picks for Week 6 of the NFL is the Cowboys (-3, 48.5) covering the spread against the Panthers in Sunday's 1:00 pm ET game. Dallas overcame CeeDee Lamb's absence by scoring 77 points in the last two games, both of which he covered. Dak Prescott has eight touchdowns and zero turnovers in that span, and his completion percentage in 2025 is the highest of his career. He's helped by a dominant run game that ranks in the top 10 in both yards per play and yards per carry after finishing 27th or worse in both metrics in 2024.
Dallas should take on a Carolina defense that has the fewest sacks (five) in the NFL and the lowest pressure level. Carolina isn't much better on offense, ranking 24th in scoring and 26th in passing. The Panthers did win last week, but Bryce Young followed each of his last four wins with straight losses. In the model, Dallas dominates the spread nearly 60% of the time with A-rated picks. See what other commands to choose here.
Another one of its Week 6 NFL predictions: the Buccaneers (-3, 47.5) cover versus San Francisco in over 50% of simulations. Between their juggling of quarterbacks, just six teams have a worse turnover differential than the 49ers, who are also getting next to nothing in their run game. The team is dead last in yards per carry, and a one-dimensional offense may struggle to keep up with the Bucs. Baker Mayfield owns a 10:1 TD:INT, and Tampa ranks in the top 10 in both scoring offense and total offense.
San Fran does have a few extra days of rest after playing last Thursday, but that hasn't necessarily been an omen to spread success. The team is just 2-4 ATS with a rest advantage over its last six games, and one can't ignore the cross-country flight that the Niners will have to make. San Francisco played three games on the East Coast last season and failed to cover in all three. The model also says the Over hits well over 50% of the time. See which other teams to pick here.
How to make Week 6 NFL picks
The model has also made the call on who wins and covers in every other game on the Week 6 NFL schedule and just revealed five teams that win by double-digits, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.
So what Week 6 NFL picks can you make with confidence, and which five teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.
Week 6 NFL betting odds, lines, live spreads, scores
