Tennessee vs. Vanderbilt prediction, odds, spread: 2025 Rivalry Week picks by proven model

Tennessee and Vanderbilt meet for the 119th time on Saturday, one of the most important matchups in series history. Both teams are ranked for the first time in this game, and a win for No. 14 Vanderbilt could send the Commodores into the College Football Playoff. The three-loss Vols, ranked 19th, fell out of the playoff picture after losing to Oklahoma earlier this month. However, the Vols bounced back with their first win in Florida since 2003 last week and could play a playoff spoiler against their in-state opponent. Tennessee running back Peyton Lewis is questionable.

Kickoff will take place at 3:30 pm ET at Neyland Stadium in Knoxville, Tennessee. The Vols are 2.5-point favorites in the latest Tennessee vs. Vanderbilt odds, and the over/under is 66.5. Before choosing between Vanderbilt and Tennessee, Check out the college football predictions with SportsLine's projection model.

New users can navigate to DraftKings Promo Codewhich offers $200 bonus bets if your bet wins + 3 months of NBA League Pass.:

The model simulates every FBS game 10,000 times and has been profitable with the highest moneyline and over/under picks since the start of the 2024 season. Anyone who follows him American football betting poking around in bookmakers and further betting sites could see strong profits.

Now the model has set its sights on Tennessee vs Vanderbilt. You can visit SportsLine now to see the selection. Here's the FBS college football chances and trends for Vanderbilt vs. Tennessee:

How to pick Tennessee vs. Vanderbilt

The SportsLine model has simulated Vanderbilt vs. Tennessee 10,000 times and is the total score is below 66.5. Tennessee's defense has improved in recent weeks, giving up an average of just 10 points per game in its last two games, with the total being lower in both of those games.

Vanderbilt pushed for more games this year, but split the over and under in four road games. Last year, these teams combined for 59 points as Pavia passed for just 104 yards in that game. The SportsLine model is projecting 62 points this year, with the total coming in under 60% of the time.

The model also says that one side of the spread hits almost 60% of the time. Select only at SportsLine..

So who will beat Vanderbilt against Tennessee and which side of the spread hits nearly 60% of the time? Visit SportsLine now to find out which side of the spread is worth moving to, all from an advanced model that's profitable on its highest moneyline and over/under picks since the start of the 2024 season.and find out.