Genomics

Mapping single-cell diploid chromatin fiber architectures using DAF-seq

Mapping single-cell diploid chromatin fiber architectures using DAF-seq

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Stergachis, A. B., Debo, B. M., Haugen, E., Churchman, L. S. & Stamatoyannopoulos, J. A. Single-molecule regulatory architectures captured by ...

Cell type inference in cell-free nucleic acid liquid biopsy

Cell type inference in cell-free nucleic acid liquid biopsy

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Liu, M. C. et al. Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA. Ann. Oncol. ...

A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording

A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording

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Design, synthesis and functional characterization of diversified U6 promoters To date, only a handful of Pol III promoters have been ...

DNA pioneer James Watson has died ― colleagues wrestle with his legacy

DNA pioneer James Watson has died ― colleagues wrestle with his legacy

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Watson received the 1962 Nobel Prize in Physiology or Medicine for his role in elucidating the structure of DNA. 1 ...

Four game-changing immunology tools to watch

Four game-changing immunology tools to watch

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Magnified view of a brain organoid with fluorescent labeling of various cell types.Photo: Thomas Hartung, Johns Hopkins University. Advanced tools ...