Genetic engineering

Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells
Li, W. et al. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 490, 407–411 (2012). Article CAS PubMed ...

A trimodal protein language model enables advanced protein searches
Altschul, S. F. et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. ...

Discovery and protein language model-guided design of hyperactive transposases
Retrieval of PiggyBac transposons Complete PiggyBac transposon sequences were gathered from all available eukaryotic genomes in the NCBI database35 (31,565 ...

Derivation of embryonic stem cells across avian species
Optimizing chicken ES cell culture conditions To develop culture conditions for deriving chicken ES cells, we isolated blastodermal cells from ...