Biotechnology
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording
Design, synthesis and functional characterization of diversified U6 promoters To date, only a handful of Pol III promoters have been ...
Clearance of intracranial debris by ultrasound reduces inflammation and improves outcomes in hemorrhagic stroke models
Animals All experiments were approved by the Institutional Animal Care and Use Committees of Stanford University. Experiments were conducted with ...
A Gene Editing Therapy Cut Cholesterol Levels by Half
In step to greater use of gene editing, a treatment that uses Crispr has successfully reduced high cholesterol in a ...
BioContextAI is a community hub for agentic biomedical systems
These authors contributed equally: Malte Kühl, Darius P. Schaub. This work was jointly led by the following authors: Stefan Bonn, ...
RNA stability enhancers for durable base-modified mRNA therapeutics
Mu, X. et al. An origin of the immunogenicity of in vitro transcribed RNA. Nucleic Acids Res. 46, 5239–5249 (2018). ...
CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci
Zheng, H. & Xie, W. The role of 3D genome organization in development and cell differentiation. Nat. Rev. Mol. Cell ...
Site-specific DNA insertion into the human genome with engineered recombinases
Ethics statement Our research complies with relevant ethical regulations. Experiments using hESC lines were performed under an allowance granted by ...
Grafting trick could let us gene-edit a huge variety of plants
Coffee plants can be propagated by grafting a shoot onto the rootstock of another plant. sirichai_asawalapsakul/Getty Images An ancient trick ...
A nonsurgical brain implant enabled through a cell–electronics hybrid for focal neuromodulation
Device fabrication The devices were fabricated on two substrates: 4″ silicon wafer (p-doped, <100>, single-side polished) and indium-tin-oxide (ITO) coated ...
KATMAP infers splicing factor activity and regulatory targets from knockdown data
Selecting the knockdown experiments We selected ENCODE knockdown RNA-seq experiments for proteins annotated as SFs24 and which had a good ...
