Bioinformatics
Integrated epigenetic and genetic programming of primary human T cells
T cell isolation and culture Human peripheral blood Leukopaks enriched for peripheral blood mononuclear cells (PBMCs) from deidentified healthy donors ...
Tumor-on-chip models of CAR-T cell therapy
Liu, H. et al. Nat. Biotechnology. https://doi.org/10.1038/s41587-025-02845-z (2025). Maulana, T.I. etc. Cell Stem cell 31989–1002.e9 (2024). Article CAS PubMed Google ...
A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors
Newick, K., O’Brien, S., Moon, E. & Albelda, S. M. CAR T cell therapy for solid tumors. Annu Rev. Med. ...
Accurate somatic small variant discovery for multiple sequencing technologies with DeepSomatic
Stratton, M. R., Campbell, P. J. & Futreal, P. A. The cancer genome. Nature 458, 719–724 (2009). Article CAS PubMed ...
Predicting functions of uncharacterized gene products from microbial communities
Armet, A. M. et al. Rethinking healthy eating in light of the gut microbiome. Cell Host Microbe 30, 764–785 (2022). ...
Programmable promoter editing for precise control of transgene expression
Domingo, J. et al. Nonlinear transcriptional responses to gradual modulation of transcription factor dosage. Preprint at bioRxiv https://doi.org/10.1101/2024.03.01.582837, peer reviewed ...
Engineered pattern recognition receptors enhance broad-spectrum plant resistance
RLP23 transfer enhances tomato resistance to multiple pathogens The Arabidopsis receptor RLP23 recognizes the conserved immunogenic epitope nlp20, which is ...
Folding-mediated secretion of pure bispecific antibodies
Carter, P. J. & Rajpal, A. Designing antibodies as therapeutics. Cell 185, 2789–2805 (2022). Article CAS PubMed Google Scholar Labrijn, ...
Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells
Li, W. et al. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 490, 407–411 (2012). Article CAS PubMed ...
Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates
Leibowitz, M. L. et al. Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing. Nat. Genet. 53, 895–905 (2021). Article ...
