Bioinformatics
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity
Palmer, S., Albergante, L., Blackburn, C. C. & Newman, T. J. Thymic involution and rising disease incidence with age. Proc. ...
High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes
Ståhl, P. L. et al. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science 353, 78–82 ...
A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels
Immunofluorescence analysis of apical–basal polarity and proliferation marker Ki67 P26N human colon organoids were grown for 2 days in BME ± ...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions
P-body purification To profile P-body contents, we adapted a fluorescence-activated sorting method29,42 using a green fluorescent protein (GFP)-LSM14A expression construct ...
Elucidating lipid nanoparticle properties and structure through biophysical analyses
Pardi, N., Hogan, M. J., Porter, F. W. & Weissman, D. mRNA vaccines—a new era in vaccinology. Nat. Rev. Drug ...
Discovery and engineering of retrons for precise genome editing
Fichter, K. M., Setayesh, T. & Malik, P. Strategies for precise gene edits in mammalian cells. Mol. Ther. Nucleic Acids ...
Democratizing protein language model training, sharing and collaboration
Drews, J. Drug discovery: a historical perspective. Science 287, 1960–1964 (2000). Article PubMed CAS Google Scholar Jacob, François & Monod, ...
Deep-learning-based virtual screening of antibacterial compounds
Mayr, L. M. & Bojanic, D. Novel trends in high-throughput screening. Curr. Opin. Pharmacol. 9, 580–588 (2009). Article CAS PubMed ...
Live imaging of late-stage preimplantation human embryos reveals de novo mitotic errors
Magli, M. C. et al. Chromosome mosaicism in day 3 aneuploid embryos that develop to morphologically normal blastocysts in vitro. ...
AlphaDIA enables DIA transfer learning for feature-free proteomics
Calibration and optimization of retention time, ion mobility and m/z During search, AlphaDIA calibrates library properties such as retention time, ...
