Bioinformatics
A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording
Design, synthesis and functional characterization of diversified U6 promoters To date, only a handful of Pol III promoters have been ...
Clearance of intracranial debris by ultrasound reduces inflammation and improves outcomes in hemorrhagic stroke models
Animals All experiments were approved by the Institutional Animal Care and Use Committees of Stanford University. Experiments were conducted with ...
BioContextAI is a community hub for agentic biomedical systems
These authors contributed equally: Malte Kühl, Darius P. Schaub. This work was jointly led by the following authors: Stefan Bonn, ...
RNA stability enhancers for durable base-modified mRNA therapeutics
Mu, X. et al. An origin of the immunogenicity of in vitro transcribed RNA. Nucleic Acids Res. 46, 5239–5249 (2018). ...
CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci
Zheng, H. & Xie, W. The role of 3D genome organization in development and cell differentiation. Nat. Rev. Mol. Cell ...
Site-specific DNA insertion into the human genome with engineered recombinases
Ethics statement Our research complies with relevant ethical regulations. Experiments using hESC lines were performed under an allowance granted by ...
A nonsurgical brain implant enabled through a cell–electronics hybrid for focal neuromodulation
Device fabrication The devices were fabricated on two substrates: 4″ silicon wafer (p-doped, <100>, single-side polished) and indium-tin-oxide (ITO) coated ...
Project Psyche Is Elevating Lepidoptera Genome Sequencing
It’s a little after 6:30 on a brisk July morning in a stone hut high in the Italian Alps. A ...
KATMAP infers splicing factor activity and regulatory targets from knockdown data
Selecting the knockdown experiments We selected ENCODE knockdown RNA-seq experiments for proteins annotated as SFs24 and which had a good ...
Growth-coupled microbial biosynthesis of the animal pigment xanthommatin
Cho, J. S., Kim, G. B., Eun, H., Moon, C. W. & Lee, S. Y. Designing microbial cell factories for ...
