Agriculture
Programmable promoter editing for precise control of transgene expression
Domingo, J. et al. Nonlinear transcriptional responses to gradual modulation of transcription factor dosage. Preprint at bioRxiv https://doi.org/10.1101/2024.03.01.582837, peer reviewed ...
Engineered pattern recognition receptors enhance broad-spectrum plant resistance
RLP23 transfer enhances tomato resistance to multiple pathogens The Arabidopsis receptor RLP23 recognizes the conserved immunogenic epitope nlp20, which is ...
Folding-mediated secretion of pure bispecific antibodies
Carter, P. J. & Rajpal, A. Designing antibodies as therapeutics. Cell 185, 2789–2805 (2022). Article CAS PubMed Google Scholar Labrijn, ...
Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells
Li, W. et al. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 490, 407–411 (2012). Article CAS PubMed ...
Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates
Leibowitz, M. L. et al. Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing. Nat. Genet. 53, 895–905 (2021). Article ...
Scaling DNA synthesis with a microchip-based massively parallel synthesis system
Guarini, S. et al. Various cholinergic routes participate in an improvement caused by CCK-8, and ActH- (1–24) in a massive ...
A trimodal protein language model enables advanced protein searches
Altschul, S. F. et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. ...
Discovery and protein language model-guided design of hyperactive transposases
Retrieval of PiggyBac transposons Complete PiggyBac transposon sequences were gathered from all available eukaryotic genomes in the NCBI database35 (31,565 ...
Detecting and quantifying circular RNAs in terabyte-scale RNA-seq datasets with CIRI3
Circular RNAs (circRNAs) are a unique class of noncoding RNA molecules characterized by their covalent circular structure1. Recent studies have ...
Derivation of embryonic stem cells across avian species
Optimizing chicken ES cell culture conditions To develop culture conditions for deriving chicken ES cells, we isolated blastodermal cells from ...
