DAVID BRANDT
GLENDALE, Ariz. (AP) — Brock Purdy threw three touchdowns in his return from a toe injury, Christian McCaffrey had two rushing touchdowns and one receiving touchdown and the San Francisco 49ers beat the disorganized Arizona Cardinals 41-22 on Sunday.
McCaffrey extended his NFL record with his 17th career game with at least one rushing touchdown and one receiving touchdown. Purdy completed 19 of 26 passes for 200 yards.
Tight end George Kittle caught two touchdown passes.
Arizona lost for the sixth time in seven games. The Cardinals were called for a franchise-record 17 penalties, also the most of any NFL team this season. They conceded 11 penalties in the first half, setting a record for the most penalties taken before half-time by any team in the last 20 years.
Arizona's Jacoby Brissett started his fifth straight game in place of the injured Kyler Murray and completed 47 of 57 passes for 452 yards, two touchdowns and two interceptions. 47 players set an NFL regular season record.
Michael Wilson caught 15 passes for a career-high 185 yards. Tight end Trey McBride had 115 receiving yards and a touchdown.
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