Ole Miss vs. Oklahoma prediction, odds, line, picks, best bets from proven model

The No. 8 Ole Miss Rebels (6-1) and the No. 13 Oklahoma Sooners (6-1) meet Saturday afternoon in a pivotal SEC matchup that will have implications for both the conference and the College Football Playoff. The Rebels' six-game winning streak was snapped last weekend with a 43-35 loss to Georgia. Oklahoma, meanwhile, routed South Carolina 26-9. Oklahoma lists running back Jovante Barnes and cornerback Gentry Williams as questionable.

Kickoff at Gaylord-Oklahoma Family Memorial Stadium in Norman, Oklahoma is at noon ET. The Sooners are 5.5-point favorites in the latest Ole Miss vs. Oklahoma odds, while the over/under is 52.5 per SportsLine consensus. Before choosing between Oklahoma and Ole Miss, Check out the college football predictions with SportsLine's projection model.

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The model simulates every FBS game 10,000 times. Since its inception, the company has generated over $2,000 in bet profits for $100 bettors on its best college football picks and is a profitable 42-30 bet when combined with the moneyline and over/under. college football picks from the beginning of 2024. Anyone who follows him American football betting poking around in bookmakers and further betting sites could see strong profits.

Now the model has set its sights on Miss Missing vs. Oklahoma. You can visit SportsLine now to see the selection. Here's the FBS college football chances and trends for the Ole Miss vs. Oklahoma matchup:

Why Ole Miss Can Cover

Lane Kiffin's offense has been dynamic all season. They rank third in the SEC in total offense (491.9) and fourth in scoring offense (37.4). Senior quarterback Trinidad Chambliss took over at quarterback after Austin Simmons suffered an early-season ankle injury and has 1,549 passing yards with eight passing touchdowns. He has over 250 passing yards and a passer rating in five straight games.

Sophomore running back Kevan Lacy comes into this game third in the SEC in rushing yards (618) and second in rushing touchdowns (10). The Texas native has three games this season with over 100 rushing yards and a score. He found the end zone twice last week. Find out which team to support at SportsLine.

Why Oklahoma Can Cover

Junior guard John Mateer is a dual-threat playmaker at center. Mateer has 1,567 passing yards, 209 rushing yards and 12 touchdowns. The top target in the passing game was junior wide receiver Isaiah Sateña III. He has 37 catches for 493 receiving yards and four touchdowns.

In his last game, Sateña III had 73 receiving yards and a score. Senior defensive lineman R. Mason Thomas enters the backfield leading the team in sacks (5.5) with 20 total tackles. Oklahoma is 1-0 ATS against ranked opponents and 3-2-1 ATS as a favorite in 2025. Find out which team to support at SportsLine.

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How to pick Ole Miss vs. Oklahoma

The SportsLine model falls short in overall scoring with 49 points. It also says that one side of the spread hits in nearly 70% of simulations. You can get the pick only at SportsLine.

So who will win Ole Miss vs. Oklahoma and which side of the spread hits nearly 70% of the time? Visit SportsLine now to find out which side of the Ole Miss vs. Oklahoma game is worth jumping on, all from an advanced model that has earned more than $2,000 on its FBS football picks since its inception.and find out.