Another week, there's another round of must-see matchups in the NFL. Week 11 brought many stunning developments, including the Jacksonville Jaguars defeating the Los Angeles Chargers and Bo Nix's Denver Broncos beat the Kansas City Chiefs. Now we have another list of intriguing developments in Week 12.
We've rounded up all the best picks and bets from CBS Sports and SportsLine and put them all in one place. So you can get a pick against the spread from our CBS Sports Experts plus additional feature-rich content for every game, including plays from top SportsLine experts and the SportsLine Projection model, best rates from our employees, survivor choice and much more. Let's jump in.
NFL odds by using Bookmaker DraftKings (unless otherwise stated). Bet on Week 12 NFL games at DraftKings Sportsbookwhere new users receive $300 in bonus bets and three free months of NBA League Pass.
Steelers and Bears
Sunday 1:00 PM ET on CBS | Broadcast enabled Paramount+
Steelers +3: SportsLine's simulation model can be used for survivor pools, which require picking one team to win each week, but never using the same team twice. This week, the model is shying away from the Bears, who are among the three-point favorites having won three in a row. Even with Aaron Rodgers' status is unclear With the quarterback suffering a broken wrist, SportsLine's model projects Pittsburgh to cover more than 50% of simulations, making Chicago a fading team. See full breakdown right here.
Patriots at Bengals
Sunday 1:00 PM ET on CBS | Broadcast enabled Paramount+
Patriots -8.5: “I don’t understand how Cincinnati can keep up this pace. New England is riding an eight-game winning streak, and Drake Maye is playing at an MVP level, leading the NFL in completion percentage (71.9%) and passing yards (2,836) entering Week 12. Now he'll have to contend with a Bengals defense that's giving up 33.4 points per game this season. Not only is that the highest in the league in 2025; This is the most points per game in a season since 1966. New York Giants.” – CBS Sports NFL Writer Tyler Sullivan why does he like new england win big.
Bet on games like Bengals vs. Patriots at BetMGM.where are the new users get back up to $1500 in bonus bets if their first bet does not win.
Giants and Lions
Sunday 1:00 PM ET on Fox | Broadcast: Fubo (try it for free)
Lions -10.5: The Lions are coming off a tough loss to Eagles and must now regroup at home against a Giants team that isn't going anywhere. … It will be about getting the Lions offense back on track after last week's disappointment. They're rolling,” CBS Sports senior NFL writer Pete Prisco. why does he like Detroit crush the G-Men.
Vikings to Packers
Sunday 1:00 PM ET on Fox | Broadcast: Fubo (try it for free)
Packers -6.5: “[The Packers have] constantly downplayed their competitors… [but] As much as I'm skeptical of Green Bay, especially when it comes to JJ McCarthy. There were points in Minnesota's loss to Chicago last week when it looked like McCarthy might remain on the bench. He's completing just 52.9% of his passes this season and is the No. 1 defenseman since then. Zach Wilson (not very good company) to start his career with an interception in five straight games,” CBS Sports NFL writer Tyler Sullivan on why is he betting big on the package?.
Seahawks vs Titans
Sunday 1:00 PM ET on Fox | Broadcast: Fubo (try it for free)
Seahawks -13.5: SportsLine AI is SportsLine's first fully automated predictive model. It continuously updates with the latest available data to identify the largest row discrepancies. After analyzing every game in Week 12, the AI says the Seahawks (-13.5) are comfortable defending against the Titans, who have lost five in a row. The model rates the Seahawks as an A+ spread pick and predicts victory with a score of 30-14 on average.
Colts to Chiefs
Sunday 1:00 PM ET on CBS | Broadcast enabled Paramount+
Colts +3.5: “I hate playing against the Chiefs at home, but I think I'll have to do it here. Colts have a chance to come to Kansas City and deal a knockout blow to the Chiefs' chances at a division title while putting their playoff hopes on life support. The Colts will enter this game with a bye, meaning the NFL's leading player, Jonathan Taylor“He'll have time to rest his legs, and I'm guessing he needed that rest because the last time he was on the field, he rushed for 244 yards,” CBS Sports NFL writer John Breech why does he like Indianapolis handing the defending AFC champions a third straight loss.
Jets at Ravens
Sunday 1:00 PM ET on CBS | Broadcast enabled Paramount+
Crows -13.5: The SportsLine Projection Model, which simulates every NFL game 10,000 times, has cost more than $7,000 per $100 of the highest-rated NFL picks since its inception. The model also enters Week 12 with a 48-33 record on top-ranked picks going back to 2024. We can tell you that one of her strongest bets for this Sunday's slate includes the Ravens, with Baltimore covering the Jets in more than 50% of simulations. The over is also used in over 80% of simulations for this AFC matchup. Read SportsLine's full coverage right here.
Browns to Raiders
Sunday 4:05 PM ET on CBS | Broadcast enabled Paramount+
Browns +3.5: “Cleveland Rookie” Sheader Sanders will be in the middle of your first career start. … [But] it's really about the Raiders' offense having to deal with Cleveland's defense. The Browns are allowing just 4.8 yards per play this season, fourth-worst in the NFL entering Week 12. Cleveland also has 10 takeaways over the past four weeks and now faces a Las Vegas offense that continues to look lost. – CBS Sports NFL writer Tyler Sullivan on why does he like the browns as potential spoilers on the road.
Jaguars to Cardinals
Sunday 4:05 PM ET on CBS | Broadcast enabled Paramount+
Jaguars -2.5: “It’s a long road for a team that gets a big win like the Jaguars did last week against the Jaguars.” Chargers. A young team may have trouble concentrating, but I still think they found something offensively last week. This will carry over here too. “They're getting the better of a struggling Arizona team,” CBS Sports senior writer Pete Prisco. why does he like jacksonville to win their third game in four weeks.
Eagles in Cowboys
Sunday 4:25pm ET on Fox | Broadcast: Fubo (try it for free)
The SportsLine Projection Model, which simulates every NFL game 10,000 times, also offers Fantasy recommendations, and this week's tip is mind-boggling: Cowboys QB8 entering Week 12 and finishing with four touchdowns may not guarantee a spot on Sunday's Fantasy lineups because he sits outside the top 15 in quarterback rankings. Why? He confronts fierce Eagles defense. But will there be Birds also come alive in attack to beat Dallas on the road? Check out SportsLine's complete analysis right here.
Falcons in Saints
Sunday 4:25pm ET on Fox | Broadcast: Fubo (try it for free)
Falcons +1.5: “Admittedly, this is a difficult situation for Atlanta.” They are on a five-game losing streak and will now be without their starting quarterback. Michael Penix Jr.. and the upper wide part Drake London due to injury. … Yes, New Orleans will get the remaining advantage from their bye, but there's still a lack of talent on this roster that makes this a real coin toss. Kirk Cousins will get the start for Atlanta, and while his career is certainly coming to an end, this is a game in which Sesame Robinson could lead him to victory.” – CBS Sports NFL Writer Tyler Sullivan why does he like the Falcons as an upset candidate against the club's NFC South rivals.
Buccaneers to Rams
Sunday 8:20pm ET on NBC | Broadcast: Fubo (try it for free)
SportsLine expert Larry Hartstein has the pulse of Los Angeles, going 26-10 (+1501) in his last 36 picks against the spread involving the Rams. So does he want Matthew Stafford, who leads the NFL with 27 touchdown passes, to outplay Baker Mayfield in a potential NFC playoff preview? Or is he going to work with Tampa Bay to resolve the Sophie Stadium debacle? Check out Hartstein's expert analysis on this topic. right here at SportsLine.
Panthers to 49ers
Monday 8:15pm ET on ESPN | Broadcast: Fubo (try it for free)
SportsLine expert Micah Roberts is 18-4 (+1360) in his last 22 picks against the 49ers' spread. So is he enjoying cruising around San Francisco at home under the “Monday Night Football” lights with Brock Purdy fresh from his dynamic return to the lineup? Or is he riding with Bryce Young and Rico Dowdle as potential primetime spoilers? Check out Roberts' expert analysis and forecast right here at SportsLine.
