NFL Thanksgiving games are often as anticipated as the food and family time that comes with the holiday, and the 2025 NFL slate of Thanksgiving games is one of the best ever. Lions vs. Packers (+3) starts at 1:00 pm ET, followed by Cowboys vs. Chiefs (-3.5) at 4:30 pm ET Crows against. Bengals (+7) nightcap at 8:20 pm ET. Joe Burrow (toe) was cleared to play and Ja'Marr Chase also returned from suspension, although receiver Tee Higgins (concussion) was ruled out. One could make an NFL parlay bet using these spreads, or include NFL picks in the total, with a money line or inserting an NFL prop. Baltimore has won five games and has won four straight against Cincinnati, making the Ravens an attractive option for your Thanksgiving NFL bet.
In terms of bets you could make, there's no shortage of stars to target, including Burrow, Amon-Ra St. Brown, Patrick Mahomes, Dak Prescott, CeeDee Lamb and Derrick Henry. Prescott threw multiple touchdown passes in five straight Thanksgiving games, but Kansas City has thrown just 11 passes in 11 games this year. He has a 1.5 over/under passer odds against the Chiefs, with a -138 NFL prop odds on the over and an intriguing plus-money payout of +108 on the under. Before you lock in any NFL Thanksgiving picks or NFL parlay games, be sure to see NFL predictions and betting tips from SportsLine's proven computer model..
LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month of SportsLine for $1. JOIN NOW.
New users can navigate to DraftKings Promo Codewhich offers $200 bonus bets if your bet wins + 3 months of NBA League Pass.:
The model, which simulates every NFL game 10,000 times, costs more than $7,000 for players with $100 in top games. NFL Pick since its creation. The model enters Week 13 with a 49-33 record in the top-rated samples going back to 2024. NFL Betting poking around in bookmakers and further betting sites could see strong profits.
Now the model has been searched Week 13 NFL Odds and recorded four solid NFL best bets on Thanksgiving. If you successfully bet on his picks, you will receive a huge payout of over 11-1. You can see just the model's NFL Thanksgiving picks at SportsLine..
New users can also check out the latest FanDuel Promo Code And get $150 in bonus bets on FanDuel if your $5 bet wins:
Best NFL Express Picks for Thanksgiving
After simulating each play 10,000 times, the model has a high score on the Ravens' defensive odds (-7, 51.5) against the Bengals. Not only has Baltimore won four straight against Cincy, but the Ravens have posted a 4-1 ATS record over the last five meetings. Baltimore's defense has been elite again this season as it has held six straight opponents to under 20 points, including a pair of top-10 offenses in the Rams and Bears. Even with Burrow expected to return, the Bengals offense is not at that level, especially with Tee Higgins (concussion) expected to be out for the game. Meanwhile, Cincinnati's defense is the worst in the NFL.
The Bengals rank last in points allowed, yards allowed and pass defense, while they perform second-to-last in run defense and third-down defense. Lack of tackling plays a big role in these rankings, as Cincy has committed just one turnover in its last four games while Baltimore has nine interceptions in its last four games. Given these discrepancies, Baltimore is projected to win by double digits and cover over 50% of simulations. See other NFL betting options hereand bet the Ravens will close here:
How to Bet on NFL Thanksgiving
The model also grabbed three other NFL picks, including a player prop that generates revenue plus money. You can see only the model's best NFL Thanksgiving bets and NFL parlay bets at SportsLine..
What are the model's best NFL picks and which Thanksgiving NFL bets should you target for an epic 11-1 payout? Visit SportsLine now to see the best Thanksgiving NFL bets from the model at 49-33 on the top-rated picks. and find out.
