Iowa vs. Vanderbilt prediction, odds, spread: 2025 ReliaQuest Bowl picks from proven model

23rd place in the ranking Iowa Hawkeyes will fight Diego Pavia and the 14th ranked player Vanderbilt Commodores at the 2025 ReliaQuest Bowl on Wednesday afternoon. Iowa finished the regular season with a 40–16 win over Nebraska on November 28, and Vanderbilt posted a 45–24 win over Tennessee on November 29. The Hawkeyes (8-4), ranked sixth in the Big Ten, are 0-4 against ranked opponents this season. The Commodores (10-2), ranked fifth in the SEC, are 4-2 in 2025 against ranked opponents. The Hawkeyes are expected to have a nearly full roster. Vanderbilt tight end Eli StowersMackey Award winner, has withdrawn and will miss the game.

Kickoff at Raymond James Stadium in Tampa, Florida is at noon ET. This will be the first meeting of the schools. The Commodores are 5.5-point favorites in the latest Vanderbilt vs. Iowa odds, while the over/under total is 46.5, according to the SportsLine consensus. Before choosing Iowa or Vanderbilt, Check out the college football predictions with SportsLine's projection model.

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The model simulates every FBS game 10,000 times and is rated 31-19. college football cash option from the start of the 2024 season.

Now the model has set its sights on Iowa vs Vanderbilt. You can visit SportsLine now to see the selection. Here's the FBS college football chances and trends for Iowa vs. Vanderbilt:

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How to choose between Iowa and Vanderbilt

After 10,000 simulations, the SportsLine model exceeds (46.5) in total. The over has scored in five of Iowa's last 10 games, including one push. The over is 7-3 in Vanderbilt's last 10 games overall.

The model depicts the Iowa quarterback. Mark Gronowski passing for over 180 yards and two touchdowns, while Pavia would throw for over 210 yards and rush for over 50 with two combined touchdowns. The teams are projected to score a combined 53 points as the over is eliminated in nearly 60% of simulations.

The model also says that one side of the spread reaches more than 60% of the time. You can see the model selection at SportsLine..

So who will beat Vanderbilt against Iowa and which side of the spread lands in over 60% of simulations? Visit SportsLine now to find out which side of Iowa vs. Vanderbilt you should jump on, all based on an advanced model that has simulated this game 10,000 times.and find out.