Seahawks vs. 49ers prediction, odds, time, spread: NFL Week 18 Saturday picks by proven model

First place in the NFC will be up for grabs when Seattle Seahawks fight with San Francisco 49ers in a key NFC West matchup on Saturday night. Seattle beats Carolina 28-10 on Sunday, while San Francisco beat Chicago 42-38. The Seahawks (13-3), who lead the NFC West, have won six straight. The 49ers (12-4), ranked second in the division, have also won six straight and are 9-2 in the conference.

Kickoff at Levi's Stadium in Santa Clara, California is set for 8:00 pm ET. The Seahawks lead the all-time series 31-24, but San Francisco has won seven of the last eight meetings. The Seahawks are 1.5-point favorites in the latest Seahawks vs. 49ers odds, and the over/under for total points scored is 48.5, according to the SportsLine consensus. Before choosing between the Seahawks and 49ers, Check out the NFL projections with SportsLine's projection model.

The model, which simulates every NFL game 10,000 times, costs more than $7,000 for players with $100 in top games. NFL Pick since its creation. The model enters Week 18 with a 53-37 record on top-rated picks going back to 2024. NFL Betting poking around in bookmakers and further betting sites could see strong profits.

Now the model has set its sights on Seahawks vs 49ers. You can visit SportsLine now to see the selection. Here NFL odds and trends for the 49ers vs. Seahawks:

Why the Seahawks might shut down

Veteran Defender Sam Darnold helps boost Seattle's offense. He completed 67.2% of his passes for 3,850 yards and 25 touchdowns with 14 interceptions and a 99.2 rating. In a 38–37 overtime win over the Los Angeles Rams on December 18, he completed 22 of 34 passes for 270 yards and two touchdowns with two interceptions. In a 38–14 win over Washington on November 2, he completed 21 of 24 passes for 330 yards and four touchdowns with one pick.

His top target is a third-year veteran receiver. Jackson Smith-Njigba. In 16 games, he has 113 receptions for 1,709 yards and 10 touchdowns. He has 27 explosive plays of 20 yards or more, including 63 long ones, with 505 yards after the catch and 74 first down conversions. In the win over Carolina, he caught nine passes for 72 yards, including 18 long ones. Find out which team to support at SportsLine.

Why the 49ers might be covering.

Defender Brock Purdy has been solid since returning from injury. In eight games this season, he has completed 69.3% of his passes for 2,040 yards and 20 touchdowns with nine interceptions and a 104.2 rating. He also had 31 catches for 126 yards and three touchdowns. In the win over Chicago, he completed 24 of 33 passes for 303 yards and three touchdowns with one interception. He also rushed six times for 28 yards and two touchdowns.

San Francisco's MVP could be Christian McCaffrey, although he missed practice on Tuesday. In 16 games this season, he has 303 catches for 1,179 yards (3.9 average) and 10 touchdowns. He also leads the 49ers in receptions with 96 receptions for 890 yards and seven touchdowns. In the win over the Bears, he caught 23 passes for 140 yards (6.1 yard average) and one touchdown, while catching four passes for 41 yards. Find out which team to support at SportsLine.

How to pick Seahawks vs. 49ers

The SportsLine model leads the overall score with 51 points. It also states that one side of the spread occurs in more than 50% of simulations. You can get the pick only at SportsLine.

So who will win the 49ers against the Seahawks and which side of the spread lands more than 50% of the time? Visit SportsLine now to find out which side of the Seahawks vs. 49ers you can fall to, all from an advanced model that has cost more than $7,000 in its NFL picks since its inception.and find out.