“Biologic therapies such as biostimulants, exosomes, platelet-rich fibrin (PRF), growth factors, and stem cell-derived products are transformative in rejuvenation by improving tissue quality from the inside out,” she explains.
However, when it comes to exosomes, she cautions that they can be very effective, but only when they remain stable and intact in the final formula. “Exosomes act as cellular messengers, carrying growth factors and proteins that support skin rejuvenation. If they are destroyed during development, they cannot deliver these signals, meaning effectiveness depends on stability.”
Dr. Engelman recommends SkinMedica TNS Revitalizing Complexwhich contains stable fibroblast-derived exosomes that remain intact and active in the finished product. “This is the first peer-reviewed study of its kind, and this is an important distinction because it confirms that the exosomes in this formula not only exist, but also reach the skin in a state where they can actually act,” she says.
Individual injections
Another new trend is personalized and customized dosing of neurotoxins such as Botox. “The main problem for patients is the fear of unnatural consequences,” explains Dr. Engelman. “However, research shows that when done correctly and in the hands of licensed and trained providers, the results can be very desirable.”
Dr. Engelman also predicts that injectable hyaluronic acid fillers such as Juvederm will remain a staple, albeit with a different role than in past years. “As the aesthetic matures, the fillers don't stop; they are improving,” she says. “Their role becomes less of a dramatic transformation and more of a quiet mastery. In 2026, hyaluronic acid will become an important enabler for a new generation of subtle, complex results that no other technology can replicate. Patients are not asking to be 'filled up'; they are asking to look like themselves, but fresher.”
As a result, fillers are shifting toward “microdosing, layering, and anatomical enhancement rather than the volume-enhancing approaches that defined the early 2020s.”
Biomimetic Ingredients
One of the biggest trends that will dominate skin care in 2026 are biomimetic ingredients (ingredients that mimic substances found naturally in our skin and body), PDRN products, and products that combat any unwanted effects of GLP-1 use.
