Duke vs. Michigan State prediction, odds, spread: 2025 college basketball picks from proven model

Fourth place in the ranking Duke Blue Devils will take on the seventh-ranked Michigan State Spartans on Saturday in a battle of the undefeated. Duke is coming off a 67-66 win over 15th-ranked Florida on Tuesday, while Michigan State crushed Iowa 71-52 on the same night. The Blue Devils (9-0), who are 3-0 against ranked opponents, are 1-0 on the road this season. The Spartans (8-0), who are 3-0 against ranked opponents, are 5-0 at home in the 2025-26 season.

Tipoff from the Breslin Center in East Lansing, Michigan, is set for noon ET. The Blue Devils are 1.5-point favorites in the latest Duke vs. Michigan State odds, per SportsLine consensus, and the over/under for total points scored is 142.5. Before choosing between Michigan State and Duke, Check out the men's college basketball projections and betting tips from the SportsLine Projection Model..

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The SportsLine Projection Model has simulated every college basketball game 10,000 times and has generated over $2,000 in revenue. rates profit for players of $100 on its highest rated college basketball chooses over the past three seasons. Anyone who follows him college basketball rates advice in bookmakers and further betting apps one could see huge profits.

Now the model has simulated Duke vs. Michigan State 10,000 times and just released his coveted men's college basketball picks and betting tips. You can visit SportsLine now to see the model selection. Here are a few men's college basketball odds and men's college basketball betting lines for Michigan State vs. Duke:

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How to pick Duke vs. Michigan State

Model SportsLine pass in total (142.5 points). The over has scored in six of the last 10 meetings between the teams.

The model projects the Blue Devils to have three players score 10.5 points or more, led by Cameron Boozer predicted 20.9 points. Meanwhile, the Spartans are projected to have three players score 9.3-plus points, led by Jackson Kohler from 10.7 points.

The SportsLine model states that one side of the spread appears in more than 70% of simulations. This pick can only be seen at SportsLine..

So who will win Michigan State against Duke, and which side of the spread lands more than 70% of the time? Visit SportsLine now to see which side of Duke vs. Michigan State spread to the back, everything from the advanced model was profitable in selecting the best players in college basketball last season.and find out.