Indiana vs. Ohio State prediction, odds, line: 2025 Big Ten Championship Game picks from proven model

The top two teams in the country will meet in the 2025 Big Ten Championship Game when the second-ranked team meets in 2025. Indiana Hoosiers compete with the best in the ranking Ohio State Buckeyes on Saturday. On November 28, Indiana defeated Purdue 56–3, and on November 29, Ohio State defeated Michigan 27–9. The Hoosiers (12-0, 9-0 Big Ten), playing in their first Big Ten title game, are 2-0 against ranked opponents this season. The Buckeyes (12-0, 9-0 Big Ten), the defending national champions, are playing in their seventh conference championship game.

Kickoff at Lucas Oil Stadium in Indianapolis will take place at 8:00 pm ET. Ohio State leads the all-time series 82-12-5, including a 38-14 win in 2024. The Buckeyes are 4-point favorites in the latest Ohio State vs. Indiana odds, and the over/under for total points scored is 47.5, according to the SportsLine consensus. Before making any choices between Indiana and Ohio, Check out the college football predictions with SportsLine's projection model.

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The model simulates every FBS game 10,000 times and has been profitable with the highest moneyline and over/under picks since the start of the 2024 season. Anyone who follows these American football betting poking around in bookmakers and further betting sites could see strong profits.

Now the model has set its sights on Indiana vs Ohio State. You can visit SportsLine now to see the selection. Here's the FBS college football chances and Ohio State vs. Indiana trends:

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Why Ohio State Can Cover

Sophomore and Heisman quarterback Julian Sayin runs the Buckeyes' offense. In 12 games, he completed 78.9% of his passes for 3,065 yards and 30 touchdowns with just five interceptions. In last week's win over Michigan, he completed 19 of 26 passes for 233 yards and three touchdowns with one interception. He completed 36 of 42 passes for 393 yards and four touchdowns in a 34-0 win over the Wisconsin Badgers on Oct. 18.

The backbone of the ground attack is the freshman running back. Bo Jackson. In 11 games, he rushed 151 times for 952 yards (6.3 average) and five touchdowns. He has rushed for 100 or more yards in three straight games and six games overall. He also has 17 receptions for 187 yards and one touchdown. In last week's win over the Wolverines, he carried 22 times for 117 yards. Find out which team to support at SportsLine.

Why Indiana Can Cover

Junior Defender Fernando Mendozaalso a Heisman candidate, leads the Hoosiers' offense. In 12 games, he completed 211 of 293 passes (72%) for 2,758 yards and 32 touchdowns with five interceptions. He also rushed 64 times for 243 yards (3.8 average) and six touchdowns. In a 31–7 win over Wisconsin on November 15, he completed 22 of 24 passes for 299 yards and four touchdowns.

Indiana's rushing attack is led by a senior running back. Roman Hemby. Through 12 games, he rushed 163 times for 866 yards (12.7 average) and one touchdown. In last week's win over Purdue, he carried 12 times for 152 yards (12.7 average) and one touchdown. He made 17 catches for 81 yards (4.8 average) and two touchdowns in a 56–6 win over UCLA on October 25. Find out which team to support at SportsLine.

How to choose between Ohio State and Indiana

Overall, the SportsLine model exceeded expectations. It also states that one side of the spread reaches more than 50% of the time. You can see the model selection at SportsLine..

So who will win Ohio State vs. Indiana and which side of the spread lands more than 50% of the time? Visit SportsLine now to find out which side of the Indiana-Ohio State spread to fall on, all from an advanced model that ranks No. 1 in moneyline and total picks.and find out.