Los Angeles Rams 28–31 Carolina Panthers
Bryce Young completed 15 of 20 passes for 206 yards and three touchdowns (two of them coming on fourth down) and the Carolina Panthers (7-6) forced Matthew Stafford into three turnovers to beat Los Angeles (9-3) and end the Rams' six-game winning streak. Carolina's defense intercepted Stafford twice, and Mike Jackson returned one for a 48-yard touchdown to end the 37-year-old's drive. NFL record of 28 consecutive passes without an interception. Derrick Brown, who flipped the ball resulting in Stafford's first choice, scored the key basket with 2:25 left to preserve the victory. Stafford completed 18 of 28 passes for 243 yards with two touchdown passes to Davante Adams, his 13th and 14th of the season.
Buffalo Bills 26-7 Pittsburgh Steelers
The Buffalo Bills (8-4) bounced back from a loss in Houston to top the Pittsburgh Steelers (6-6). Josh Allen scored a touchdown and ran for another, and Joey Bosa sacked Aaron Rodgers to give Christian Benford the opportunity to turn the game around with a 17-yard score. James Cook rushed for 144 yards as the Bills accumulated 249 yards on the ground and controlled the clock for nearly 42 minutes. Allen threw for just 123 yards on a windy day at Acresure Stadium. His eight-yard touchdown run early in the fourth quarter essentially ended the game. It was the 76th rushing touchdown of Allen's career, breaking the NFL record for most touchdowns by a quarterback, which he briefly shared with Cam Newton.
Houston Texans 20–16 Indianapolis Colts
Suddenly it was a race in the AFC South after the Houston Texans won their fourth game in a row, this time against the division rivals Indianapolis Colts. With quarterback C.J. Stroud back in the lineup, the two-time defending South Champion Texans are back in the division race. The Texans are 7-5, haven't lost a division game this season and are in third place in the division, one win behind the Colts and Jaguars (8-4).
Stroud completed 22 of 35 passes for 276 yards and one interception, and Nico Collins caught five passes for 98 yards and a run for the score. Stroud completed 9 of 13 passes in the second half, including 3 of 3 on third down. Houston's defense held the NFL's No. 1 scoring offense to fewer than 20 points for the first time this season and kept Colts running back Jonathan Taylor out of the end zone. Taylor had 85 rushing yards and 36 receiving yards. The Colts were stopped on seven of their 10 attempts on third down.
San Francisco 49ers 26–8 Cleveland Browns
Brock Purdy rushed for a touchdown and scored another in the second half, and the San Francisco 49ers (9-4) spoiled Sheader Sanders' first home start for the Cleveland Browns (3-9). San Francisco scored 19 unanswered points after trailing in the second quarter. All three of their touchdowns came from short fields, and they capitalized on turnovers and long returns. Purdy completed 16 of 29 passes for 168 yards. San Francisco star Christian McCaffrey added 74 yards from scrimmage and a touchdown. Sanders passed for 149 yards and a touchdown for Cleveland.
Minnesota Vikings 0-26 Seattle Seahawks
The Seattle Seahawks (9-3) shut out an opponent for the first time in more than a decade in a win over the Minnesota Vikings (4-8). Ernest Jones IV made the first of five takeaways from the Seahawks' dominant defense. Jones returned the interception 84 yards for a touchdown. Seattle's last shutout win was a 26-0 win over Chicago in September 2015. The win was a mismatch as the Seahawks faced undrafted rookie quarterback Max Brosmer. Seattle moved into first place with the Los Angeles Rams in the NFC West, while Minnesota lost its fourth straight.
Arizona Cardinals 17–20 Tampa Bay Buccaneers
Baker Mayfield and the Tampa Bay Buccaneers (7-5) defeated the Arizona Cardinals (3-9) in three games. Mayfield threw a two-yard pass to All-Pro left tackle Tristan Wirfs and Tampa Bay's defense held on for the final two minutes. Mayfield started after missing the second half of the Rams' 34-7 loss with a left shoulder injury. He threw for 194 yards and ran for 27 to help the Bucs remain first in the NFC South. Arizona has lost four straight and nine of 10.
Las Vegas Raiders 14–31 Los Angeles Chargers
Justin Herbert scored two touchdowns while playing through a non-throwing hand injury and Kimani Vidal had a 59-yard scoring run in the Los Angeles Chargers' victory over the surging Las Vegas Raiders (2-10). Quentin Johnston and Ladd McConkey had catches and Vidal rushed for a career-high 126 yards as the Chargers (8-4) beat their longtime AFC West rivals for the fourth straight time. Geno Smith passed for 165 yards and two touchdowns to Brock Bowers in their sixth straight loss to the Raiders, who have just one win since Week 1.
Jacksonville Jaguars 25–3 Tennessee Titans
Trevor Lawrence threw for 229 yards and two touchdowns to lead the Jacksonville Jaguars to a 25-3 victory over the Tennessee Titans. With the win, Jacksonville (8-4) moves even with the Indianapolis Colts at the top of the AFC South heading into the first of two matchups between the teams next week. The Jaguars beat the Titans (1-11) 272-188. Tennessee was 2 of 12 on third downs and 1 of 4 on fourth downs. Jakobi Meyers had his best day since being traded to Jacksonville from the Las Vegas Raiders in November, with six catches for 90 yards and a touchdown. The Jaguars sacked Tennessee quarterback Cam Ward three times and Josh Hines-Allen had two sacks.
New Orleans Saints 17–21 Miami Dolphins
De'Von Achane rushed for 134 yards and a touchdown, Riley Patterson made four field goals and the Miami Dolphins won their third straight game by holding off the New Orleans Saints. Achane scored on the game's first possession and the Dolphins (5-7) never relinquished the lead despite shaky play from Tua Tagovailoa, who completed 12 of 23 passes for 157 yards with an interception. Rookie Tyler Shaw passed for 239 yards and two touchdowns for the Saints (2-10).
Atlanta Falcons 24–27 New York Jets
As time expired, Nick Faulk kicked a 56-yard field goal through thick fog to lift the New York Jets to victory over the Atlanta Falcons. Tyrod Taylor went 19 of 33 for 172 yards and a touchdown and also ran for a score. Adonai Mitchell had eight receptions for 102 yards and a touchdown. Kirk Cousins went 21 of 33 for 234 yards and a touchdown for the Falcons, who lost for the sixth time in seven games. With the win, the Jets broke two games.
