Inter brought back Marcus Thuram with Lautaro Martinez and Carlos Augusto, while Milan brought back Adrien Rabiot behind Rafael Leao and Christian Pulisic for the Derby della Madonnina.
It's starting on San Siro at 19.45 GMT.
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You can follow the developments and action happening in today's Serie A games on the Liveblog.
MILAN, ITALY – NOVEMBER 23: General view outside the stadium before the Serie A match between Milan and Juventus at Stadio Giuseppe Meazza on November 23, 2024 in Milan, Italy. (Photo by Marco Luzzani/Getty Images)
It's not just a fierce local rivalry, but a battle for the top of the table as the race for the Scudetto looks tighter than ever this season.
There are injury issues on both sides, as well as good news from the treatment room.
Denzel Dumfries had not recovered from an ankle injury while on international duty and joined Henrikh Mkhitaryan, Raffaele Di Gennaro and Thomas Palacios in the stands.
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Carlos Augusto moves to the right flank to provide cover in place of Luis Enrique, with Petar Sučić preferred to Piotr Zielinski in midfield.
Thuram returns to the starting line-up for the first time since September 30 along with Lautaro Martinez, with Francesco Acerbi getting the nod over Yann Bissek.
MILAN, ITALY – FEBRUARY 2: Referee Daniele Chiffi reacts to Internazionale's Lautaro Martinez during the Serie A match between Milan and Internazionale at Stadio Giuseppe Meazza on February 2, 2025 in Milan, Italy. (Photo by Marco Luzzani/Getty Images)
Max Allegri is experiencing his first Derby della Madonnina for the first time since 2013his last stint on the Milan bench.
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Santiago Jimenez is still out with an ankle problem, while Zachary Atekame is also ruled out with a soleus injury.
The good news for Allegri is that Pulisic, Rabiot and Fikayo Tomori are all set to return to the starting XI, while Rafael Leao is still settling into his more central attacking role.
Davide Bartesaghi is preferred over Pervis Estupinan on the left flank.
Rabiot has not played since the 0-0 draw with Juventus on October 5 and is reunited with Luka Modric to form an experienced midfield pairing.
In the last five official meetings with Milan between Serie A, Italian Cup and Italian Super Cup, Inter managed only two draws.
MILAN, ITALY – SEPTEMBER 23: AC Milan's Adrien Rabiot applauds the fans after the final whistle of the Coppa Italia Frecciarossa round of 16 match between AC Milan and American Lecce at Stadio Giuseppe Meazza on September 23, 2025 in Milan, Italy. (Photo by Jonathan Moscrop/Getty Images)
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Official line-ups of Inter – Milan teams
Inter: Summer; Akanji, Acerbi, Bastogne; Carlos Augusto, Barella, Calhanoglu, Sučić, Dimarco; Thuram, Lautaro Martinez
Milan: Maignan; Tomori, Gabbia, Pavlovich; Saelemaekers, Fofana, Modric, Rabiot, Bartesaghi; Pulisic, Leao
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Serie A live broadcasts: Inter-Milan, Cremonese-Roma, Lazio-Lecce
