NFL Week 12 2025 schedule: Rams, Bucs, Bills and Cowboys all in action

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Week 12 of the 2025 NFL season will feature some strong matchups and the first start for a highly touted rookie quarterback.

Los Angeles Rams On Sunday night, quarterback Matthew Stafford will take on Tampa Bay Buccaneers quarterback Baker Mayfield. The matchup will pit the MVP favorite from Stafford against a quarterback who is on the cusp of competing for the award in Mayfield. The NFC Heavyweight Championship battle may be the matchup fans look forward to in January.

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Indianapolis Colts quarterback Daniel Jones throws a pass during the first half of an NFL football game against the Atlanta Falcons on Sunday, Nov. 9, 2025, in Berlin, Germany. (AP Photo/Martin Meissner)

Fans constantly ask the question: “Are the Indianapolis Colts real?” There will be no better way to prove that this is the case than to take on the cream of the crop in the AFC in the Kansas City Chiefs. Jonathan Taylor has also been mentioned as an MVP candidate as he averages 113 yards per game.

Elsewhere, the Philadelphia Eagles take on the Dallas Cowboys in an extremely important matchup for both teams. The Eagles have been winning this year, but there have been questions about their complex offense. Meanwhile, Dak Prescott is playing at an MVP level and faces a tough test to see how realistic Dallas is as a playoff contender.

Sheader Sanders his first NFL start as a defensive end for the Cleveland Browns. He'll have to deal with Las Vegas Raiders star Maxx Crosby, who will haunt him the entire game.

Jalen Hurts in the crowd

Philadelphia Eagles quarterback Jalen Hurts (1) talks with teammates during the first half of an NFL football game against the Detroit Lions, Sunday, Nov. 16, 2025, in Philadelphia. (AP Photo/Matt Rourke)

Read below to see what the rest of the NFL schedule has to offer.

Thursday, November 20

Sunday, November 23

  • Pittsburgh Steelers @ Chicago Bears (1:00 p.m. ET)
  • New England Patriots @ Cincinnati Bengals (1:00 p.m. ET)
  • New York Giants @ Detroit Lions (1:00 p.m. ET)
  • Minnesota Vikings @ Green Bay Packers (1:00 p.m. ET)
  • Seattle Seahawks @ Tennessee Titans (1:00 p.m. ET)
  • Indianapolis Colts @ Kansas City Chiefs (1:00 p.m. ET)
Matthew Stafford throws the ball to a receiver

Los Angeles Rams quarterback Matthew Stafford passes during the first half of an NFL football game against the Seattle Seahawks on Sunday, November 16, 2025, in Inglewood, California. (AP Photo/Gregory Bull)

Baker Mayfield with Sean Tucker

Tampa Bay Buccaneers running back Sean Tucker (44) celebrates with quarterback Baker Mayfield (6) after scoring against the Buffalo Bills during the second half of an NFL football game on Sunday, November 16, 2025, in Orchard Park, New York. (AP Photo/Jeffrey T. Barnes)

  • New York Jets @ Baltimore Ravens (1:00 p.m. ET)
  • Cleveland Browns @ Las Vegas Raiders (4:05 p.m. ET)
  • Jacksonville Jaguars @ Arizona Cardinals (4:05 p.m. ET)
  • Philadelphia Eagles @ Dallas Cowboys (4:25 p.m. ET)
  • Atlanta Falcons @ New Orleans Saints (4:25 p.m. ET)
  • Tampa Bay Buccaneers @ Los Angeles Rams (8:20 p.m. ET)

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Monday, November 24

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