Today’s early best bets to target: Friday’s top sports picks for Knicks vs. Heat, Louisville vs. Clemson, more

The New York Knicks will be without Jalen Brunson for the first time this season on Friday after the team's star point guard suffered an ankle injury on Wednesday. However, no other New York players were listed on this morning's injury report, meaning the Knicks should still have talented players like Karl-Anthony Towns, OG Anunoby and Mikal Bridges, which will be enough for SportsLine's projection model to have the Knicks among the 5.5-point favorites as one of the best sports bets for the matchup at 7:00 pm ET.

The model also has Illinois State coming in as a 16.5-point underdog against USC in college basketball, and one of SportsLine's top experts has Louisville vs. Clemson in college football in its best bets on Friday.

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Regardless of whether you are studying NBA betting, American football betting, college basketball bettingor anything else on the Friday sports schedule, there are plenty of online sports betting options and our team can help point you in the right direction. Our computer model and experts will rank all the biggest events every day, and they're offering their best sports bets right now.

Best bets for early Friday

  • Knicks (-5.5) vs. Heat
  • Illinois State +16.5 vs. USC
  • Louisville vs. Clemson: Over 51.5 points

Combining these three picks into Wednesday's parlay on FanDuel will result in a payout of +596 (risk $100 to win $596). Bet on FanDuel here:

Best bets for NBA Friday

  • Game: Miami Heat vs. New York Knicks
  • Pick: Knicks -5.5 (-110)

The Knicks are 7-4 this season, including 7-1 at home when they host the Heat on Friday. Even with Jalen Brunson (ankle) missing, the Knicks have enough talent to win and cover the spread in this game, led by Karl-Anthony Towns, who is averaging 20.2 points and 12.6 rebounds per game this season. Last season, the Knicks won all three head-to-head games against Miami, including their lone home game, by 21 points. According to the model, the Knicks will cover 63% of the simulations.

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Best college basketball bets on Friday

  • Game: Illinois State Redbirds vs. USC Trojans (7:00 p.m. ET)
  • Pick: Illinois +16.5 (-112)

Illinois State can't compete with USC in brand appeal, but the Redbirds are coming off a 22-win season and return the top two scorers from last year's successful team. Chase Walker, a 6-foot-7 junior forward, led Illinois in scoring (15.2 points per game) and rebounding (6.2 per game) last season, while junior guard Johnny Kinziger was second in scoring with 14.6 points per game. USC lost its top three scorers from last year as the new roster is still developing early-season chemistry. The model views 16.5 points as too many points to give to a team returning top talent from a 20-win season because According to the model, Illinois covers the spread in 75% of simulations.

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Best bets for Friday college football

  • Game: Clemson Tigers vs. Louisville Cardinals (7:30 p.m. ET)
  • Pick: Clemson +2.5 (-108

“It was a disappointing campaign for Clemson Dabo Swinney, who went just 4-5 today. Still, the Tigers have improved since their late September bye…as long as QB Cade Klubnik is available, which he will be on Friday night.” Legendary SportsLine pundit Bruce Marshall said:. “Dabo's boys are also thinking about revenge after last year's 33-21 home loss to the Cards. Since a rousing defeat in Miami in mid-October, the Villa had looked poor, toiling against heavy underdogs BC and VPI before losing at home last week to nearly three touchdowns from California. Just as he did last season at USC, when a fast start in September preceded him being benched in November, Card QB Miller Moss has seen his effectiveness plummet as this season progresses.”

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