The Lone Star State will take center stage for many as the Week 11 college football picks will be two ranked matchups on the slate featuring Texas teams. The Big 12 features Texas Tech vs. BYU, with the ninth-ranked Red Raiders holding a 10.5-point lead over the No. 8 Cougars, according to the latest college football odds. Next up in the SEC, Texas A&M vs. Missouri views the third-ranked Aggies as 7-point favorites over 19th-ranked Mizzou. BYU and Texas A&M are two of the last four undefeated teams entering Week 11. However, there are still some intriguing matchups to bet on in Week 11 college football.
No. 4 Alabama vs. LSU (+10.5) is a classic rivalry as the Tigers play their first game in the post-Brian Kelly era. Auburn also moved on from coach Hugh Freeze and is 6.5 points behind 15th-ranked Vanderbilt. It shouldn't be overlooked that Notre Dame vs. Navy (+27.5) will play for the 98th time, and the game has one of the biggest spreads in college football in Week 11. Before locking in any Week 11 college football picks for these or other games, Be sure to check out the latest college football predictions for Week 11, based on SportsLine's proven model..
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Now he turned his attention to the latest college football chances and week 11 American football betting lines on the spread, money line and over/under. Head here to see each selection..
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Best College Football Predictions for Week 11
One of the college football picks the model received for Week 11: The top-ranked Ohio State Buckeyes (-29.5, 48.5) play Purdue on Saturday at 1:00 pm ET. OSU's 12-game winning streak is the longest in the country, and the 2025 defense was absolutely dominant. The Buckeyes' 6.9 points are the fewest of any Big Ten team in the first eight games of a season in 40 years. Meanwhile, Purdue ranks 109th (out of 136 FBS teams) in scoring as the Boilermakers have lost seven straight games. Considering Ryan Day boasts a 53-1 record against unranked opponents, including a +32.6 margin of victory, the model has Ohio State covering over 50% of the time. See what other choices the model likes here.
Another prediction: Clemson (-1.5, 56.5) will close out Florida State in Saturday's 7:00 pm ET game more than 50% of the time. The season hasn't gone according to plan for either team, but the Tigers are 2-2 over their last four while FSU is just 1-4 over their last five. Clemson's defense is capable of making Florida State one-dimensional, as the Tigers have held three of their last four opponents to 85 yards or less. This could be a major problem for the Seminoles, especially with QB Thomas Castellanos struggling on the road. His team has been blown out completely in each of his last five starts on the road, and he has just one pass to two picks on the road this year. Under is projected to strike nearly 60% of the time. See other selections of models here.
How to Make College Football Picks for Week 11
The model also determined who will win and cover in every FBS matchup in Week 11, and projects multiple upsets in big games, including a complete win for a Big Ten underdog. At SportsLine, you can get all the picks for every game., and for a limited time, you can use promo code CHAMPIONSHIP to get your first month at SportsLine for $1.
So what college football picks can you make with confidence, and which Big Ten favorite will be eliminated? Check out the latest college football odds below, then visit SportsLine to see which teams are winning and cover the spread, all based on a proven computer model that has generated over $2,000 in profit since its inception.and find out.
Odds for standout college football matchups in Week 11
Complete college football picks, odds and predictions for Week 11 can be found here.
(odds are subject to change)
Saturday, November 8
Indiana vs. Penn State (+14.5, 50.5)
Georgia vs. Mississippi State (+9.5, 56.5)
BYU vs. Texas Tech (-10.5, 51.5)
Ohio State vs. Purdue (+29.5, 48.5)
Vanderbilt vs. Auburn (+6.5, 45.)
Texas A&M vs. Missouri (+7, 48.5)
Florida State vs. Clemson (-1.5, 56.5)
Navy vs. Notre Dame (-27.5, 55.5)
LSU vs. Alabama (-10, 49.5)
