Arizona (3-5) — Seattle (6-2)
Sunday, 4:05 pm EST, CBS
BetMGM NFL Odds: Seahawks at 6 1/2
Against the spread: Seahawks 6-2, Cardinals 5-3.
Series record: Seahawks lead 30-22-1.
Last meeting: Seahawks beat Cardinals 23-20 in Arizona on Nov. 9, 2025.
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Last week: The Seahawks beat the Commanders 38-14 on Sunday night; The Cardinals beat the Cowboys 27-17 on Monday night.
Cardinals offense: total (21), rushing (20), passing (20), scoring (19).
Cardinals defense: overall (20), rushing (12), passing (23), scoring (T-11).
Seahawks offense: total (9), rushing (22), passing (4), scoring (5).
Seahawks defense: total (11), rushing (2), passing (18), scoring (5).
Turnover differential: Seahawks minus-3; The Cardinals are plus-5.
Cardinals player to watch
WR Marvin Harrison Jr. had a career-high seven catches for 96 yards and a touchdown in Arizona's win over the Dallas Cowboys on Monday night. Last year's fourth overall pick quickly developed a rapport with QB Jacoby Brissett after Kyler Murray went down with a foot injury. Harrison, who has 492 yards and three touchdowns this season, is in good shape for his first 1,000-yard season.
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Seahawks player to watch
WR Rashid Shahid was acquired in a trade with New Orleans on Tuesday for two draft picks and is in the midst of a career season. As veteran pass rusher Cooper Kupp continues to battle an injury and leading NFL wide receiver Jackson Smith-Njigba is drawing more and more attention, Shahid could have plenty of options against Arizona's 23rd-ranked passing defense.
Key match
The last time the Seahawks and Cardinals squared off, Seattle's passing game resulted in six sacks, including 1 1/2 from Leonard Williams. The elusive Kyler Murray will not be Seattle's quarterback in this game; instead, it will be Brissett trying to avoid the Seahawks pass.
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Key injuries
Cardinals: Murray (foot) has missed the last three games after injuring his foot Oct. 5 against the Tennessee Titans. CB Max Melton is in concussion protocol. LB Mack Wilson had sore ribs and left the Cowboys game in the fourth quarter. LB BJ Oulari could return after missing about a season and a half with torn multiple knee ligaments.
Seahawks: TE Elijah Arroyo (calf), G Christian Haynes (chest), WR Tory Horton (groin), DT Jarran Reed (wrist) all practiced. TE AJ Barner (calf) participated in limited practice. WR Cooper Kupp (heel, hamstring), WR Darek Young (quadriceps), WR Jake Bobo (calf), CB Josh Jobe (concussion) did not practice.
Episode notes
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Since 2021, the Seahawks have won eight straight games against their NFC West opponents.
Statistics and more
Arizona's Calais Campbell has 13.5 sacks against the Seahawks over his 18-year career. … TE Trey McBride has had 10 straight games with at least five catches. This is only the fourth time in NFL history that a tight end has reached that milestone. … Brissett completed 65.8 percent of his passes for 860 yards, six touchdowns and one interception in three starts. He also ran for 49 yards and a touchdown. … In Monday's win over the Cowboys, Arizona's rookie class of DL Walter Nolen III, CB Will Johnson, LB Cody Simon, CB Denzel Burke and LB Jordan Burch combined for 19 tackles, one interception, one sack, four passes defended, two forced fumbles, two tackles for loss and two special teams tackles. … The Cardinals ranked 30th in the NFL in rushing yards through the first five games of the season. Brissett played the final three games and the Cards' ranking moved up to 20th. … Cardinals DE Josh Sweat had five quarterback hits against the Cowboys. That's the best mark of any NFL player this season. … The Cardinals' 10-point win over the Cowboys was the first time in eight games they have played a game decided by more than a TD. … The Seahawks are 6-2 for the first time since 2020. Seattle went 10-7 last season and hasn't had a losing season since 2021 under Pete Carroll. … The Seahawks are 1-1 against NFC West opponents this season. They lost their home opener to the 49ers 17–13 but beat the Cardinals 23–20. … Sam Darnold's 116 quarterback rating ranks second in the league. … Wide receiver Jackson Smith-Njigba, who led the Seahawks in receiving yards in 2024, leads the NFL in that category this season. His 948 yards are 117 more than Ja'Marr Chase, who played one more game than Smith-Njigba. … Tyrese Knight had a season-high 10 tackles in the Seahawks' latest win. … The Seahawks have nine interceptions this season, fourth in the NFL. The Bears lead the league with 13. … The Seahawks have 27 sacks, tied for third in the NFL, while the offense has allowed just nine sacks. … Seahawks K Jason Myers went 1-for-1 on field goal attempts in Seattle's last game. Myers scored 14 of his 18 on the season. He missed just four hits last season.
Fantasy advice
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The Seahawks' secondary is still a bit of a mess, while their front seven was one of the best in the league in 2024. Brissett figures to throw early and often, which should benefit his top option in Harrison. It's worth starting with last year's No. 4 overall pick.
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