Spurs vs. Mavericks odds, Flagg vs. Wembanyama predictions: NBA picks for Oct. 22 from proven model

Southwest Division contenders will open the 2025-26 NBA season when the team San Antonio Spurs fight with Dallas Mavericks on Wednesday evening. It's also a matchup of two of the league's biggest young players who were recently selected first overall, with Victor Wembanyama leading the Spurs and Cooper Flagg making his Mavs debut. Dallas lost in play-in play last year after reaching the NBA Finals in 2023-24, and San Antonio hasn't made the postseason since 2018-19. The Spurs (34-48), who finished fourth in the division a year ago, were 13-27 on the road last season. The Mavericks (39-43), third in the Southwest Division, were 22-18 at home. De'Aaron Fox (hamstring) was out for San Antonio and Kyrie Irving (knee) was out for Dallas.

The announcement from the American Airlines Center in Dallas is scheduled for 9:30 p.m. ET. Dallas is a 3.5-point favorite in the latest Spurs vs. Mavericks odds, according to SportsLine consensus, while the over/under for total points scored is 223.5. Before choosing between the Mavericks and Spurs, Check out NBA projections and betting tips from the SportsLine Projection Model.

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The SportsLine Projection Model has simulated every NBA game 10,000 times and has generated over $10,000 in revenue. rates profit for players of $100 on its highest rated NBA Pick over the past seven seasons. The model enters the 2025-26 NBA season with a stunning 160-118 on all top-rated NBA picks, earning nearly $4,000. He also went 24-11 (69%) in the NBA's best against the spread last season. Anyone who follows him NBA betting advice in bookmakers and further betting apps one could see huge profits.

Now the model has simulated Spurs vs Mavericks 10,000 times and just revealed his coveted NBA picks and betting predictions. You can visit SportsLine now to see the model selection. Here are a few NBA odds and NBA betting lines for Mavericks vs. Spurs:

Spurs vs Mavericks lineup:

Dallas -3.5 on DraftKings

Spurs vs Mavericks Over/Under:

223.5 points

Spurs vs. Mavericks moneyline:

Dallas -157, San Antonio +132

Spurs vs. Mavericks picks:

See the picks on SportsLine

Broadcast of the Spurs – Mavericks match:

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Why the Mavericks might be covered

Top draft pick Cooper Flagg makes his NBA debut. The former Duke star and former National College Player of the Year averaged 19.2 points, 7.5 rebounds, 4.2 assists, 1.4 steals and 1.4 blocks in 30.7 minutes per game. He holds the ACC freshman scoring record with 42 points against Notre Dame on Jan. 11. Among his other honors last season, he was a first-team All-American, ACC Player of the Year, ACC Rookie of the Year and named to the ACC All-Defensive Team.

Guarding also helps strengthen the offense. Klay Thompson. In 72 games last year, all starts, he averaged 14 points, 3.4 rebounds and two assists in 27.3 minutes of play. The five-time All-Star scored a season-high 29 points on seven 3-pointers against Golden State on Dec. 15, 2024. For his career, he averages 19.1 points on 2,697 three-pointers, which ranks fifth most in NBA history. Find out which team to support at SportsLine.

Why Spurs might cover

Third year veteran Victor Vembanyama helps the pace of San Antonio's offense. In 46 games a year ago, all starts, he averaged 24.3 points, 11 rebounds, 3.8 blocks, 3.7 assists and 1.1 steals in 33.2 minutes. He is also solid defensively and has blocked shots in 85 straight games, a Spurs record. Last December, in a win over Portland, Wembanyama became the sixth player in NBA history to score 30-plus points and 10-plus blocked shots in a single game.

Fifth year veteran. Devin Wassell – another goal option for Spurs. In 64 games last season, including 53 starts, he averaged 16.3 points, 4 rebounds, 2.9 assists and 1.3 steals in 31 minutes. On March 4, he scored a career-high 37 points on 14-of-17 shooting, including 8-of-10 from three-point range, while adding 11 rebounds. He made a 3-pointer in 25 straight games. Find out which team to support at SportsLine.

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How to choose between Spurs and Mavericks

The SportsLine model simulated the Spurs vs. Mavericks 10,000 times and topped the total with 227 points. The model also says that one side of the spread hits in nearly 70% of simulations. You can head over to SportsLine to see the model's NBA picks..

So who will win the Spurs vs. the Mavericks and which side of the spread ends up in nearly 70% of simulations? Visit SportsLine now to see which side of the Spurs vs. Mavericks move back, all from a model that paid more than $10,000 for the highest-rated picks in the NBA.and find out.

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