The NFL's Week 7 schedule concludes with a Monday Night Football doubleheader. The Detroit Lions will host the Tampa Bay Buccaneers at 7:00 pm ET and the Seattle Seahawks will host the Houston Texans at 10:00 pm ET. The Lions vs. Buccaneers game has an over/under of 53.5 points and the Seahawks vs. Texans game has an over/under of 41.5 points, so these potential play streams could play a role in NFL DFS strategy. The NFL's DFS lineup includes Baker Mayfield, Jared Goff, Jameer Gibbs, Amon-Ra St. Brown, Jackson Smith-Njigba and Nico Collins. All are expected to become popular NFL DFS players and centerpieces of NFL DFS lineups.
Who are the best NFL DFS picks for Lions vs. Buccaneers and Seahawks vs. Texans, and which daily Fantasy players should you target to differentiate NFL DFS lineups and NFL DFS stacks? Before making any NFL DFS picks for Monday Night Football on sites like DraftKings and FanDuel, Be sure to check out NFL DFS lineup, strategy and lineup tips from SportsLine NFL daily fantasy expert Jimmy Keillor..
Kaylor is NFL Betting and DFS expert for SportsLine, who opened the 2022 NFL season by winning Thursday's NFL Showdown Millionaires' Contest presented by DraftKings. He beat out over 355,000 other competitors in the competition and also has several five-figure tournament wins on his DFS resume. Keillor has covered the NFL and college football for nearly a decade as a member of the Pro Football Writers Association of America, and his experience as a former college and NFL player gives him a unique perspective when constructing his fantasy lineups and betting picks.
Now Keillor has turned his attention to Monday Night Football and has just locked in his top daily fantasy football picks. You can see his Monday Night Football DFS picks and analysis only at SportsLine..
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Best NFL DFS Picks, Lineups and Stacks for Monday Night Football
One of Keillor's top picks for Monday Night Football is Buccaneers quarterback Baker Mayfield. The former No. 1 overall pick's re-emergence with the Buccaneers in 2024 was a revelation. He threw for 4,500 yards, 41 touchdowns and had a passer rating of 106.8 in 17 games. He also rushed for a career-high 378 yards, showcasing his dual-threat ability.
Through six weeks in 2025, Mayfield continued to improve, posting 1,539 passing yards, 12 touchdowns and just one interception in six games with a 108.5 passer rating. He is now among the top contenders for the 2025 NFL MVP award. See who else you can sign up here.
Part of Keillor's optimal NFL DFS strategy also includes adding Lions running back Jameer Gibbs to the lineup. The former Alabama standout has become a dynamic offensive weapon for the Lions. In 2024, he rushed 250 times for 1,412 yards and 16 rushing touchdowns and added 52 receptions for 517 yards and four receiving touchdowns. That performance earned him his second Pro Bowl nod and established him as one of the league's most effective all-around defensive backs.
He continued his productive run into 2025, carrying the ball 87 times for 390 yards (4.5 yards per carry) and finding the end zone four times while adding 23 receptions for 112 yards. While his average per carry is down slightly from 2024, his explosiveness and versatility still drive his value to the Lions' offense. You can see the rest of Keillor's NFL DFS picks here..
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How to Make NFL DFS Lineups for Monday Night Football
Keillor also has his sights set on another underrated player who could blow up the crowds on “Monday Night Football.” This choice can be the difference between winning tournaments and cash games or going home empty-handed. You can see who it is and get the rest of Keillor's NFL DFS picks at SportsLine..
So who did Jimmy Caylor include in his optimal NFL DFS lineups for the Monday Night Football doubleheader, and which under-the-radar NFL DFS picks have tremendous value? Visit SportsLine now to see the best NFL DFS picks, rankings, tips and stacks – all from SportsLine's proven DFS expert, who won the one-game millionaire-making tournament.and find out.
